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12 July 2021
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Using science to determine product development direction

At Sibelius, we pride ourselves on supporting our customers through the research and development of consumer health products. The main statement on our website describing our Chronoscreen™ platform is ‘looking for science to determine your development direction?’ because the platform gives managers the ability to clearly determine the best source and best ingredients to invest into. Chronoscreen™ provides the data on life extension to determine the sources and ingredients worthy of additional spend to develop further.


Chronoscreen™ provides a powerful platform for the screening and identification of biologically active natural products that have the potential for development into ingredients that are beneficial to human health.

  • Gain invaluable insights on complex extracts to drive further decision making and manage risk before committing to expensive clinical trials
  • Gain a competitive advantage for finished products and formulations with access to a new level of understanding of extracts
  • Expand product pipelines with new evidence-based product innovation and suggest potential synergistic combinations
  • Give products a route to patent protection by highlighting the distinction between biologically active ingredients


Testing for biometric indicators of ingredients offers many benefits to businesses. However, when looking at different types of assay testing, a key consideration is to understand exactly what the testing performs and on what kind of extracts.

One of a kind with C.elegans

Chronoscreen™ utilizes the roundworm, Caenorhabditis elegans (C. elegans), a whole organism model with many physiological similarities to humans including a digestive and nervous system. The validity of the C. elegans model for biomedical research was even recognised by the award of the 2002 Nobel Prize in Physiology or Medicine7.

Many of the pathways known to affect the biological processes associated with ageing and longevity have been conserved through history across a range of species; thus allowing meaningful, transferrable results to be obtained from model organisms and applied to human biology2.

The whole organism approach

The Chronoscreen™ platform can be successfully applied for biological testing of a broad range of natural ingredients. It can identify and confirm the evidence of their potential health benefits, from which we can then determine the pathways essential for the ingredient’s activity. This helps to address consumer demands and concerns as well as regulatory and policy issues.

Each ingredient has a chemical fingerprint that can be used to determine the biometric indicators. What makes Chronoscreen™ unique is that our platform allows us to test whole extracts. The C.elegans are not only able to eat the whole ingredient, but they’re also able to diffuse the ingredients directly into their cuticles, which allows us to monitor the life extension of the chemical fingerprint working together; whilst many other testing platforms are only able to test singular components at a time.

Sibelius validity

Chronoscreen™ can be summarised into three main stages: identification of botanicals, selecting sources, and validating the selected sources. Our process allows us to work with our customers every step of the way to ensure the best, validated, results possible to drive confident direction.


Sibelius Natural Products has already tested more than 750 natural ingredients and products and on the back of these tests, we have confidently launched four ingredients that showed superior life extension. At Sibelius, our team of experts are on hand to guide you through the process



Contact us to learn how Chronoscreen™ can drive your ingredient research and development forward.

About Sibelius Natural Products
Sibelius is a developer and marketer of high-value, clinically validated natural ingredients for use in dietary supplements, foods and beverages. The company is focused on building modern scientific evidence behind well-known botanicals, helping consumers to make informed decisions about the supplements they choose to purchase. Sibelius’ ingredient portfolio supports unique claims associated with cognition, sleep, anxiety, inflammation, cardiovascular health and men’s health. For more information, please fill in the form below:
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