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19 November 2021
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Take care of your heart health with Sibelius™: LactoMato

Health-related problems constitute the leading cause of death worldwide, taking an estimated 17.9 million lives each year.1 According to the American Heart Association, more than one in three adult men deal with these issues.2 Many studies prove that men are more likely than women to develop heart problems. But why heart problems are a male issue? According to studies, the average man tends to pay less attention to following a healthy diet and is more likely to delay visiting a doctor until it is too late. Smoking, lack of physical activity, and an unhealthy diet constitute some of the main factors that contribute to the risk of heart problems. Based on statistics, up to 20,000 deaths in the UK can be attributed to smoking. In addition, one in three adults do not achieve the recommended physical activity and have bad eating habits3.

The beneficial role of Lycopene

Did you know that Lycopene is a key player when it comes to heart health? Lycopene is a carotenoid that is commonly found in tomatoes and other fruits, and it is known for its antioxidant properties. Considerable evidence suggests that the consumption of lycopene has beneficial effects on people’s health such as reducing the risk of heart-related problems.4 A study of middle-aged men published in the journal Neurology found out that high levels of lycopene in the blood are associated with a lower risk of cardiovascular problems. In detail, men with the greatest amounts of lycopene in their blood had a 55% lower chance of having any kind of stroke.5 Similarly, a 2014 study from the University of Cambridge showed significant improvement in vascular health and function in response to the intake of the Sibelius™: LactoMato formulation has discovered that with the increase of blood lycopene levels, the incidents of heart problems would fall significantly, which could contribute towards the reduced incidence of heart problems observed with higher blood lycopene levels. 6

Why Sibelius™: LactoMato?

Seeing the beneficial role of lycopene in people’s health, Sibelius decided to take an active role in developing Sibelius™: LactoMato, which is a natural and highly bioavailable lycopene-rich tomato extract. Based on clinical studies, a conveniently small dose of it can have significant benefits in cardiovascular health and men’s health. Sibelius™: LactoMato can be used in food, beverage, and dietary supplement applications.

But why is Sibelius™: LactoMato so special? For a better understanding of the superiority of Sibelius™: LactoMato, it is necessary to understand the complexity of lycopene’s bioavailability. Concerning lycopene, several areas play a role in its bioavailability. First, lycopene absorption from tomatoes increases when they are cooked, and when they are ingested with fat.7 The process of absorbing lycopene involves many steps including the release from the food matrix, transfer to the intestinal wall, absorption, transportation to the lymphatic system, and then it is released into the blood.8 Sibelius™: LactoMato absorption and bioavailability studies show impressive results.9  When it comes to heart health, a study using Sibelius™: LactoMato showed a significant reduction in lipoprotein oxidation activity in just 2-weeks (over 70-percent reduction). (Figure 1)

Figure 1: Changes in lipoprotein oxidation activity observed in the volunteers in the study, following 8 weeks daily supplementation with 350mg of Sibelius™:LactoMato formulation (providing 7mg lycopene). Data shows average +/- SD.

At Sibelius, we work closely with our customers to create market-leading products using the best ingredients from the best source. Our research and quality testing provide our customers with the confidence to make marketing-changing products.

Download our whitepaper to learn more about our Sibelius™: LactoMato:



  1. World Health Organization (2021), 'Cardiovascular diseases'.
  2. American Health Association (2013) ‘Men & Cardiovascular Diseases’. 
  3. New Victoria Hospital (2020) ‘Cardiovascular Risk In Men - Why Is Heart Disease A Male Problem’. 
  4. Arab, L. and Steck, S. (2000) ‘Lycopene and cardiovascular disease’, The American Journal of Clinical Nutrition, 71(6), pp. 1691S–1695S. 
  5. Karppi, J. et all. (2012) ‘Serum lycopene decreases the risk of stroke in men’, Neurology
  6. Gajendragadkar et al. (2014) ‘Effects of Oral Lycopene Supplementation on Vascular Function in Patients with Cardiovascular Disease and Healthy Volunteers: A Randomised Controlled Trial’.
  7. Gartner C, Stahl W, Sies H. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr 1997;66:116-22
  8. Story EN, Kopec RE, Schwartz SJ, Harris GK. An update on the health effects of tomato lycopene. Annu Rev Food Sci Technol 2010;1:189-210
  9. Richelle et al. (2002) ‘A Food-Based Formulation Provides Lycopene with the Same Bioavailability to Humans as That from Tomato Paste1,2’, Human Nutrition and Metabolism.
About Sibelius Natural Products
Sibelius is a developer and marketer of high-value, clinically validated natural ingredients for use in dietary supplements, foods and beverages. The company is focused on building modern scientific evidence behind well-known botanicals, helping consumers to make informed decisions about the supplements they choose to purchase. Sibelius’ ingredient portfolio supports unique claims associated with cognition, sleep, anxiety, inflammation, cardiovascular health and men’s health. For more information, please fill in the form below:
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